Ambiguous results of an attempt to withdraw barbiturates in epilepsy patients with intellectual disability

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Ambiguous results of an attempt to withdraw barbiturates in epilepsy patients with intellectual disability

Phenobarbital and primidone frequently have adverse effects on mental functions. Therefore, an attempt was made to taper barbiturates in 85 patients out of a resident population with epilepsy and intellectual disability who were selected according to clinical criteria. The objectives were to reduce the use of barbiturates, to improve the patients' cognitive and psychological state, and to reduc...

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Diagnostic accuracy of audio-based seizure detection in patients with severe epilepsy and an intellectual disability

UNLABELLED We evaluated the performance of audio-based detection of major seizures (tonic-clonic and long generalized tonic) in adult patients with intellectual disability living in an institute for residential care. METHODS First, we checked in a random sample (n=17, 102 major seizures) how many patients have recognizable sounds during these seizures. In the second part of this trial, we fol...

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Intellectual disability and epilepsy in down syndrome.

UNLABELLED Down Syndrome (DS) is the most common genetic cause of mental retardation, with a reported frequency of epilepsy between 1.4-17% (1). There is a paucity of data in the literature regarding epilepsy in Down syndrome and its relation to intellectual disability. OBJECTIVES The purpose of this article is to analyze the association of epilepsy in children with DS - frequency and type of...

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Mutations in HECW2 are associated with intellectual disability and epilepsy

BACKGROUND De novo mutations are a frequent cause of disorders related to brain development. We report the results of screening patients diagnosed with both epilepsy and intellectual disability (ID) using exome sequencing to identify known and new causative de novo mutations relevant to these conditions. METHODS Exome sequencing was performed on 39 patient-parent trios to identify de novo mut...

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ژورنال

عنوان ژورنال: Seizure

سال: 2009

ISSN: 1059-1311

DOI: 10.1016/j.seizure.2008.07.006